Mario has had many jobs over the years, but besides his plumber job, he also has a long history of being a doctor. Let’s take a close look at all of Dr. Mario Games Ranked From Best To Worst. For these rankings, we will use the scores the games have been given on Metacritic.
Dr. Mario Express/Dr. Mario Online RX (76/72 – DS/Wii)

Dr. Mario Online Rx for the Wii as WiiWare and Dr. Mario Express for the DS as DSiWare retained the core gameplay while introducing online multiplayer and a portable format. Dr. Mario Online RX even allowed players to challenge opponents worldwide.
Dr. Mario 64 (71 – N64)

Dr. Mario 64 for the Nintendo 64 brought the series into the 3D era while maintaining its classic gameplay. What sets it apart is the addition of multiplayer modes, allowing friends to compete or cooperate in virus-busting action. The introduction of new characters and animated cutscenes added depth to the game’s charming world.
Dr. Mario: Miracle Cure (69 – 3DS)

Dr. Mario: Miracle Cure for the Nintendo 3DS offered a mix of classic Dr. Mario gameplay and new elements like the Miracle Cure item. It provided a dose of nostalgia but didn’t change much from the other games, resulting in a somewhat safe bet for Nintendo.
Classic NES Series: Dr. Mario (66 – GBA)

The game that started it all, Dr. Mario for the Nintendo Entertainment System (NES), remains a classic in the puzzle genre. With its straightforward yet challenging gameplay, players match colored capsules to eliminate viruses. The game’s simplicity, coupled with its escalating difficulty levels, made it an instant hit. Sadly, the original game does not have an official rating, so we picked the GBA port, this is basically exactly the same as the original NES version.
Dr. Luigi (65 – Wii U)

Dr. Luigi for the Wii U introduced Luigi as the star physician. The game featured a new L-shaped capsule, adding a twist to the classic formula. While the gameplay remained engaging, Dr. Luigi didn’t stray far from its predecessor’s formula.
Dr. Mario World (58 – iOS)

Dr. Mario World for iOS introduced a free-to-play model with in-app purchases. While the game retained the classic gameplay, it incorporated a stamina system that limited playtime.
If you enjoyed these rankings, why don’t you check out our ranked page? Here you can see all the games we have ranked. Please let us know what series you would wanna see us rank in the comments or on Twitter/Discord! September is Mario Month, so make sure to check that page for Mario content every day for this month.